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  • Prescribing Information
  • Instructions for Use
  • Medication Guide
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Trulicity (dulaglutide) injection logo
  • Prescribing Information
  • Instructions for Use
  • Medication Guide
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    How to Use Trulicity

    Whether you are new to Trulicity, or about to transition to a different dose, the information on this site can help you get started.

    What do you need to know to get started?

    How to save

    How to save

    The benefits of Trulicity

    The benefits of Trulicity

    how to take Trulicity

    How to take Trulicity

    Trulicity Savings Card

    Getting access to savings

    You may be eligible to pay as little as $25 for 12 Trulicity pens with the Trulicity Savings Card.

    Subject to Lilly USA, LLC’s (Lilly’s) right to terminate, rescind, revoke or amend the Trulicity Savings Card Program (“Card” or "Program") eligibility criteria and/or Card terms and conditions which may occur at Lilly’s sole discretion, without notice, and for any reason, the Card expires and savings end on 12/31/2025. Card savings are not available to patients without commercial drug insurance or who are enrolled in any state, federal, or government funded healthcare program, including, without limitation, Medicaid, Medicare, Medicare Part D, Medicare Advantage, Medigap, DoD, VA, TRICARE®/CHAMPUS, or any state prescription drug assistance program. Offer void where prohibited by law and subject to change or discontinue without notice. Card activation is required. Subject to additional terms and conditions, which can be found here .

    Coming soon!

    How Trulicity can help adults with type 2 diabetes*

    *Along with diet and exercise.

    Male Trulicity patient holding the Trulicity Pen

    Checkmark A1C reduction
    Trulicity may offer lasting A1C improvements. In a study, some Trulicity users saw a significant improvement when their A1C was measured after 6 months, and it was still improved after they had been taking Trulicity for 1 year.

    Checkmark The majority of people reached an A1C under 7%
    In Trulicity studies with other medication, 50% to 67% of patients with an average starting A1C of 8% to 8.6% reached an A1C < 7% across 4 doses.

    Checkmark Starts acting from the first dose
    Trulicity is a non-insulin option that helps your body release the insulin it's already making.

    Checkmark People lost an average of 10 lbs on the 4.5 mg dose
    Trulicity is not a weight loss drug. In studies with other diabetes medications, weight change in adults ranged from +0.4 lbs (0.75 mg) to −10.1 lbs (4.5 mg).

    Select Important Safety Information:

    Ask your healthcare provider how to recognize possible serious side effects and what to do:
    Low blood sugar (hypoglycemia). Your risk for getting low blood sugar may be higher if you use Trulicity with another medicine that can cause low blood sugar, such as a sulfonylurea or insulin. Signs and symptoms of low blood sugar may include dizziness or light-headedness, confusion or drowsiness, headache, blurred vision, slurred speech, fast heartbeat, sweating, hunger, shakiness, feeling jittery, weakness, anxiety, irritability, or mood changes.

    Coming soon!

    Select Important Safety Information:

    Ask your healthcare provider how to recognize possible serious side effects and what to do:

    Serious allergic reactions. Stop using Trulicity and get medical help right away if you have any symptoms of a serious allergic reaction which may include: swelling of your face, lips, tongue or throat, problems breathing or swallowing, severe rash or itching, fainting or feeling dizzy, or a very rapid heartbeat.

    Choosing your Trulicity day

    Trulicity is designed to fit into your busy life. Trulicity is taken once a week. On your Trulicity day, you can take your dose at any time of the day, with or without food. So start by picking the best day for you and mark it as your Trulicity day. Do your best to stick to the same day every week.

    If you missed your Trulicity dose, or need to change your Trulicity day, read below.

    If you'd like to change your Trulicity day, you can. If it's been more than 3 days since your last dose, you can switch. If it's been fewer than 3 days since your last dose, wait until the following week to take the dose on your new Trulicity day.‡

    ‡ Do not take 2 doses of Trulicity within 3 days of each other.

    Quotes The doctor just told me to read the instructions because she said it was easy to use*. So, I took her word, and she was right, it is easy to use* Trulicity. Quotes

    - Cesar

    Real Trulicity User

    Using your Trulicity Pen

    00:00-00:24
    [Trulicity logo]

    NARRATOR: Trulicity is a once-weekly injectable prescription medicine for adults and children 10 years of age and older with type 2 diabetes used to improve blood sugar along with diet and exercise and also proven to reduce the risk of major cardiovascular events, such as death, heart attack, or stroke in adults with type 2 diabetes mellitus who have heart disease or multiple risk factors.

    CAPTION: Once weekly Trulicity® (dulaglutide) injection 0.5 mL, 0.75 mg, 1.5 mg, 3.0 mg, 4.5 mg

    00:24-00:33
    [The outside of a two-story home; an alarm clock is sounding in the background; a woman silences the alarm, picks up her phone, and gets out of bed; she stretches]

    WOMAN: I’d better get my day started.

    CAPTION: Actor portrayal

    00:33-00:42
    [Woman brushes her teeth while she looks at her calendar on her phone]

    WOMAN: Hmm… Looks like it’s my Trulicity Day.

    CAPTION: 8AM: Feed dog

    CAPTION: 9AM: Call in meeting

    CAPTION: 10AM: Meet office manager

    CAPTION: Trulicity Day

    00:42-00:55
    [Woman walks out of her bedroom, ready for work; continues to look at her phone calendar as she walks; son walks out of his room and waves to his mom]

    WOMAN: I take Trulicity once a week to activate my body to release its own insulin, like it’s supposed to.

    CAPTION: 11AM Conference call

    CAPTION: 12PM Business lunch with new clients

    CAPTION: Trulicity helps activate my body to release its own insulin.

    00:55-01:01
    [Woman walks downstairs; in kitchen, woman continues to view her phone calendar, appears to be a bit overwhelmed; woman puts phone on kitchen island]

    WOMAN: Whew. It’s going to be busy! I’m going to start my day with once-a-week Trulicity.

    CAPTION: Trulicity helps activate my body to release its own insulin.

    CAPTION: 2PM Interview

    CAPTION: 5PM Kids’ soccer games

    CAPTION: 7PM Pick up dry cleaning, dog food

    01:01-01:05
    [Woman prepares coffee in her kitchen]

    WOMAN: I think it’s really easy to use, and I’ve heard most people think so, too.

    CAPTION: 94%: In a study, 94% of people said it was easy to use.

    CAPTION: The key administration steps

    01:05-01:16
    [Woman continues to prepare coffee; 3 preparation steps show images of the pen]

    WOMAN: 3 steps: uncap the pen, place and unlock, press and hold, and I’m done for the week.

    CAPTION: 1 Uncap the pen

    CAPTION: 2 Place and unlock

    CAPTION: Press and hold

    01:16-01:26
    [Woman fills dog’s bowl with food and puts the bowl on the floor; dog comes over to eat; 7 icons on screen show the days of the week]

    WOMAN: It really isn’t very hard to fit into my schedule.

    CAPTION: Trulicity works all week to help your body release its own insulin when it’s needed.

    01:26-01:41
    [Image of instructions; woman opens refrigerator, box containing 4 Trulicity pens is on her refrigerator shelf; woman takes out a Trulicity pen and closes refrigerator door]

    WOMAN: I keep my Trulicity in the refrigerator, but when I travel, it’s good to know I can keep it out for up to two weeks.

    CAPTION: Instructions for Use

    CAPTION: Read the Instructions for Use included with your pen.

    CAPTION: Keep Trulicity in your refrigerator

    CAPTION: Do not freeze the pen

    CAPTION: Keep out of direct heat and light

    01:41-01:52
    [Woman’s family members walk into kitchen to leave for school, work; she hugs them; Trulicity pen stands upright on kitchen island; woman washes her hands at kitchen sink]

    WOMAN: Better wash my hands.

    CAPTION: Leave the base cap on until you are ready to inject.

    CAPTION: Get ready by washing your hands.

    01:52-02:04
    [Woman picks up Trulicity pen; she inspects the name, dosage, and expiration date on pen, as well as the quality]

    CAPTION: Make sure you have the right medicine.

    CAPTION: And it HAS NOT expired.

    CAPTION: Check the pen to make sure it is NOT damaged.

    CAPTION: Inspect the medicine to make sure it is NOT cloudy, discolored, or has particles in it.

    02:04-02:11
    [Basic images of front and back of human body; abdomen and thighs are highlighted on the image labeled “Front”]

    WOMAN: I know I can give myself Trulicity in my belly or thigh. Since last week I used my thigh,
    I think I’ll try my belly.

    02:11-02:16
    [Upper arms are highlighted on the front and back images of human body]

    WOMAN: Next week, I think I’ll try my upper arm, but I’ll need my husband to help me.

    CAPTION: Rotate your injection site each week. You may use the same area of your body, but be sure to choose a different injection site in that area.

    02:16-02:28
    [Woman holds up Trulicity pen; makes sure it’s locked; removes the gray cap; pulls up her blouse slightly and holds the pen against her stomach; unlocks pen; presses and holds it to her stomach]

    WOMAN: First, I’m going to make sure it’s locked. Yes, it is. Now, I’ll remove the gray cap and hold it firmly against my stomach. Now, I’ll unlock it. Thankfully, I don’t even have to see the needle.

    CAPTION: Uncap the pen

    CAPTION: Place and unlock

    CAPTION: Press and hold

    02:28-02:38
    [Woman holds pen firmly against her stomach; we hear two clicks; woman removes pen and pulls down blouse]

    WOMAN: All I need to do is press the green button until I hear a CLICK. I’ll just hold it until I hear a second click. There we go. That’s click number two!

    02:38-03:00
    [Woman inspects her Trulicity pen; close up of pen reveals the gray plunger at bottom of pen; woman puts pen in sharps container, under her kitchen sink]

    WOMAN: I know my injection is complete because I can see the gray plunger. All done! Now I need to put this somewhere safe.

    CAPTION: If you don’t have a sharps container, you can recycle an empty laundry detergent bottle, or a coffee can. Just make sure it has a closable lid and is puncture-resistant.

    CAPTION: DO NOT throw away (dispose of) pens in your household trash.

    CAPTION: DO NOT recycle your used sharps disposal container.

    CAPTION: KEEP sharps container away from children and pets.

    03:00-03:08
    [Woman removes travel coffee mug from a kitchen cabinet; pours her coffee into it; puts lid on mug and walks away]

    WOMAN: That really only took a few minutes out of my day— and I feel good about the step I’ve taken to help manage my diabetes for the week.

    03:08-03:15
    [Woman prepares a sandwich, presumably for lunch]

    NARRATOR: Trulicity is for type 2 diabetes. It isn’t for people with type 1 diabetes or children under 10 years of age.

    CAPTION: Tell your healthcare provider if you are nursing, pregnant, or plan to be or are scheduled to have surgery or other procedures that use anesthesia or deep sleepiness

    03:15-03:23
    [Woman away from kitchen island, holding her packed lunch, coffee mug, and phone; prepares her purse and belongings to leave]

    NARRATOR: Don’t take Trulicity if you’re allergic to it, you or your family have medullary thyroid cancer, or multiple endocrine neoplasia syndrome type 2.

    CAPTION: Symptoms may include swelling of your face or throat, problems breathing or swallowing, severe rash or itching, dizziness, or rapid heartbeat

    03:23-03:35
    [Woman picks up her belongings and walks out of the kitchen]

    NARRATOR: Stop Trulicity and call your healthcare provider right away if you have an allergic reaction, a lump or swelling in your neck, severe stomach pain, vision changes, or diabetic retinopathy.

    CAPTION: Tell your healthcare provider right away if you experience upper stomach pain, yellow skin or eyes, fever, or clay-colored stools

    03:35-03:43
    [Woman stops to pick up folders and additional items needed for work]

    NARRATOR: Serious side effects may include pancreatitis and gallbladder problems. Taking Trulicity with sulfonylurea or insulin raises low blood sugar risk.

    CAPTION: Trulicity is not recommended for people with severe stomach or intestinal problems. Tell your healthcare provider if you have history of diabetic retinopathy.

    03:43-03:52
    NARRATOR: Side effects include nausea, vomiting, and diarrhea, which can lead to dehydration and may worsen kidney problems.

    CAPTION: Side effects include nausea, diarrhea, vomiting, decreased appetite, indigestion, belly pain, and fatigue

    CAPTION: Drink plenty of fluids

    03:52-04:05
    [Woman checks her hair in a mirror; walks out of her house]

    WOMAN: Well, that takes care of my Trulicity for the week. And it only took a few minutes. Off to work!

    CAPTION: Trulicity is a prescription medicine

    CAPTION: Talk to your healthcare provider or call The Lilly Answers Center at 1-800-LillyRX (1-800-545-5979).

    04:05-04:17
    [Trulicity logo]

    CAPTION: Once weekly Trulicity® (dulaglutide) injection 0.5 mL, 0.75 mg, 1.5 mg, 3.0 mg, 4.5 mg

    CAPTION: Please see safety throughout this video and the Indications and Safety Summary including Warning about possible thyroid tumors including thyroid cancer adjacent to this video and available Instructions for Use for the pen by clicking the links on the website.

    CAPTION: Trulicity® and its delivery device base are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates. Trulicity is available by prescription only.

    CAPTION: PP-DG-US-4949 12/2024 ©Lilly USA, LLC 2024. All rights reserved.


    Read the Instructions for Use included with your pen.

    Every dose of Trulicity comes in the easy-to-use* pen, so you can continue to have the same experience with once-weekly Trulicity, regardless of the dose you've been prescribed.

    *In a study, 94% of adults with type 2 diabetes who used the Trulicity Pen found it easy to use.

    Step 1: Uncapping the Trulicity Pen
    Step 1: Uncapping the Trulicity Pen

    Uncap the pen

    Step 2: Pack and Unlock the Trulicity Pen
    Step 2: Pack and Unlock the Trulicity Pen

    Place and unlock

    Step 3: Press and hold the Trulicity Pen
    Step 3: Press and hold the Trulicity Pen

    Press and hold

    Choosing your injection site

    Your healthcare provider can help you choose the areas on your body that are best to use Trulicity. You may use the same area of your body, but be sure to use a different spot in that area every time. Suggested areas to use Trulicity are your upper arm, abdomen, or thigh (see diagram). Another person should give you the injection in the back of your upper arm.

    Trulicity injection site figure
    Coming soon!

    For adults with type 2 diabetes

    More dose options. More treatment possibilities.

    Trulicity has 4 dose options to better fit your diabetes needs. And because each dose comes in the easy-to-use* pen, you can continue to have the same experience with once-weekly Trulicity, regardless of the dose you've been prescribed.

    *In a study, 94% of adults with type 2 diabetes said it was easy to use. Read the Instructions for Use included with your pen.

    Four dose options for the Trulicity Pen

    What side effects might occur when starting Trulicity?

    Managing side effects   →

    SAFETY SUMMARY WITH WARNINGS

    Warnings:

    Trulicity may cause tumors in the thyroid, including thyroid cancer. Watch for possible symptoms, such as a lump or swelling in the neck, trouble swallowing, hoarseness, or shortness of breath. If you have any of these symptoms, tell your healthcare provider.

    • Do not use Trulicity if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC).
    • Do not use Trulicity if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
    • Do not use Trulicity if you are allergic to dulaglutide or other ingredients in Trulicity.

    Ask your healthcare provider how to recognize the serious side effects below and what to do if you think you have one:

    Inflamed pancreas (pancreatitis). Stop using Trulicity and call your healthcare provider right away if you have severe pain in your stomach area (abdomen), with or without vomiting, that will not go away. You may feel the pain from your abdomen to your back.
    Low blood sugar (hypoglycemia). Your risk for getting low blood sugar may be higher if you use TRULICITY with another medicine that can cause low blood sugar, such as a sulfonylurea or insulin.
    Signs and symptoms of low blood sugar may include dizziness or light-headedness, confusion or drowsiness, headache, blurred vision, slurred speech, fast heartbeat, sweating, hunger, shakiness, feeling jittery, weakness, anxiety, irritability, or mood changes.
    Serious allergic reactions. Stop using Trulicity and get medical help right away if you have any symptoms of a serious allergic reaction which may include swelling of your face, lips, tongue or throat, problems breathing or swallowing, severe rash or itching, fainting, or feeling dizzy, or very rapid heartbeat.
    Acute kidney injury. In people who have kidney problems, diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration). This may cause kidney problems to get worse.
    Severe stomach problems. Stomach problems, sometimes severe, have been reported in people who use Trulicity. Tell your healthcare provider if you have stomach problems that are severe or will not go away.
    Changes in vision. Tell your healthcare provider if you have changes in your eyesight (vision) during treatment with Trulicity.
    Gallbladder problems. Gallbladder problems have happened in some people who take Trulicity. Tell your healthcare provider right away if you get symptoms of gallbladder problems, which may include pain in your upper stomach (abdomen), fever, yellowing of skin or eyes (jaundice), clay-colored stools.
    Food or liquid getting into the lungs during surgery or other procedures that use anesthesia or deep sleepiness (deep sedation). Trulicity may increase the chance of food getting into your lungs during surgery or other procedures. Tell all your healthcare providers that you are taking Trulicity before you are scheduled to have surgery or other procedures.

    Common side effects

    The most common side effects of Trulicity include nausea, diarrhea, vomiting, abdominal pain and decreased appetite, indigestion, and fatigue.

    These are not all the possible side effects of Trulicity.

    Tell your healthcare provider if you have any side effects. You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch .

    Before using

    • Your healthcare provider should show you how to use Trulicity before you use it for the first time.
    • Before you use Trulicity, talk to your healthcare provider about low blood sugar and how to manage it.

    Review these questions with your healthcare provider:

    • Do you have other medical conditions, including problems with your pancreas, kidneys, liver, or stomach, or have a history of diabetic retinopathy (vision problems related to diabetes)?
    • Do you take other diabetes medicines, such as insulin or sulfonylureas?
    • Are you scheduled to have surgery or other procedures that use anesthesia or deep sleepiness (deep sedation)?
    • Are you pregnant or plan to become pregnant or breastfeeding or plan to breastfeed?
    • Do you take any other prescription medicines or over-the-counter drugs, vitamins, or herbal supplements?

    How to take

    • Read the Instructions for Use that come with Trulicity.
    • Use Trulicity exactly as your healthcare provider says.
    • Do not share your Trulicity pen, syringe, or needles with another person.
    • Do not give Trulicity to other people.
    • If you take too much Trulicity, call your healthcare provider or seek medical advice promptly.

    Learn more

    Trulicity is a prescription medicine. For more information, call 1-844-TRU-INFO (1-844-878-4636) or go to www.TRULICITY.lilly.com.

    This summary provides basic information about Trulicity but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your healthcare provider. Be sure to talk to your healthcare provider about Trulicity and how to take it. Your healthcare provider is the best person to help you decide if Trulicity is right for you.

    DG CON HL BS 11NOV2024

    Trulicity® and its delivery device base are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

    INDICATIONS

    Trulicity® (Trῡ-li-si-tee) is for adults and children 10 years of age and older with type 2 diabetes used along with diet and exercise to improve blood sugar (glucose). Trulicity is also used in adults with type 2 diabetes to reduce the risk of major cardiovascular events (problems having to do with the heart and blood vessels) such as death, heart attack, or stroke in people who have heart disease or multiple cardiovascular risk factors.

    • It is not known if Trulicity can be used in people who have had inflammation of the pancreas (pancreatitis). Trulicity is not for use in people with type 1 diabetes and is not recommended for use in people with severe stomach or intestinal problems. It is not known if Trulicity is safe and effective in children under 10 years of age.
    • Trulicity is given through an injection (needle). You take it once a week by injecting it under the skin of your stomach, thigh, or upper arm.

      For more information:
      call 1-844-TRU-INFO
      (1-844-878-4636)

      This site is intended for US residents ages 18 and over.
      PP-DG-US-3169 12/2024 ©Lilly USA, LLC 2024. All rights reserved.
      TRICARE® is a registered trademark of the Department of Defense (DoD), DHA.
      Trulicity® and its delivery device base are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

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