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Trulicity (dulaglutide) injection logo
  • Prescribing Information
  • Instructions for Use
  • Medication Guide
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Trulicity (dulaglutide) injection logo
  • Prescribing Information
  • Instructions for Use
  • Medication Guide
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    Trulicity patient working on a car with his son

    In adults with type 2 diabetes

    Trulicity is proven to help lower A1C*

    *Along with diet and exercise

    It lowers blood sugar from the first dose, and seeing the impact of one change may motivate you to make more of them.

    In adults with type 2 diabetes

    You have the power to lower your A1C and Trulicity can help

    Voltron Blood Droplet Icon

    With Trulicity, most people reached an A1C under 7%*

    *In Trulicity studies with other diabetes medication, 50% to 67% of adults reached an A1C <7% with an average starting A1C of 8% to 8.6% across 4 doses.

    Voltron Calendar Icon

    Trulicity is taken once weekly

    Voltron Scale Icon

    People lost an average of 10 lbs on the 4.5 mg dose†

    †Trulicity is not a weight loss drug. In studies with other diabetes medications, weight change in adults ranged from +0.4 lbs (0.75 mg) to −10.1 lbs (4.5 mg).

    Select Important Safety Information:

    Do not use Trulicity if you are allergic to dulaglutide or other ingredients in Trulicity.

    How Trulicity helps control blood sugar levels in adults with type 2 diabetes

    Liver icon

    It can limit how much sugar gets into your blood from your liver

    Stomach icon

    It helps slow down how quickly food leaves your stomach

    Pancreas icon

    It helps your pancreas release insulin in response to high levels of sugar in your blood after you eat

    Trulicity is designed to fit into your busy life

    Is life getting in the way of managing your type 2 diabetes? Trulicity could fit into your busy life.

    Trulicity is taken:

    Checkmark With an easy-to-use pen*

    Checkmark Once a week

    Checkmark At any time of day

    Checkmark With or without food


    *In a study, 94% of adults with type 2 diabetes said it was easy to use. Read the Instructions for Use included with your pen.

    Man searching in shed

    Select Important Safety Information:

    Ask your healthcare provider how to recognize possible serious side effects and what to do:
    Inflamed pancreas (pancreatitis). Stop using Trulicity and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away. You may feel the pain from your abdomen to your back.

    Gallbladder problems. Gallbladder problems have happened in some people who take Trulicity. Tell your healthcare provider right away if you get symptoms of gallbladder problems, which may include pain in your upper stomach (abdomen), fever, yellowing of skin or eyes (jaundice), clay-colored stools.

    Quotes By taking Trulicity once per week, it allows me more time to enjoy my riding with my friends. Quotes

    - Chuck

    Trulicity User, 2022

    Why Trulicity users choose Trulicity

    - Lynda
    Trulicity User, 2018


    00:00-00:24
    [Trulicity logo]

    NARRATOR: Trulicity is a once-weekly injectable prescription medicine for adults and children 10 years of age and older with type 2 diabetes used to improve blood sugar along with diet and exercise and proven to reduce the risk of major cardiovascular events in adults with type 2 diabetes with known heart disease and multiple risk factors.

    CAPTION: Once weekly Trulicity® (dulaglutide) injection 0.5 mL, 0.75 mg, 1.5 mg, 3.0 mg, 4.5 mg

    CAPTION: Trulicity is not approved for use in children under 10 years of age.

    00:24-00:32
    [Lynda is sitting in her creative space at home, happily making jewelry]

    LYNDA: My name is Lynda. I am semi-retired, but I still design jewelry. I still have so much fun with it.

    CAPTION: Lynda: Real Trulicity User

    00:32-00:39
    [Close-up of Clayton standing in his kitchen, then packing his suitcase]

    CLAYTON: My name is Clayton, and I'm an aerospace consultant, and I'm a person that travels extensively.

    CAPTION: Clayton: Real Trulicity User

    00:39-00:49
    [Lynda using a rock polishing machine in her creative space]

    LYNDA: When I first learned that I had diabetes, it changed everything instantly, for me. It requires life changes.

    00:49-00:57
    [In a car, driving through the mountains; standing in his kitchen, talking to camera]

    CLAYTON: Well, it was kind of devastating at first because I didn't know what it was and what I was going to have to do to survive it and live a good life with it.

    CAPTION: Doubt

    00:57-01:12
    DR. EDEN: Diabetes takes away what the body does naturally. And so, when I introduce patients to Trulicity and I say, “I've got a therapy,” and I tell them what it does, I talk about A1C reduction, I talk about how it complements what the body does, and then I tell them it's once a week. They go, “You're kidding me!”

    CAPTION: Dr. Eden M., DO: High Lakes Health Care
    CAPTION: Different

    CAPTION: Trulicity is not insulin

    CAPTION: It helps your body release its own insulin

    CAPTION: Trulicity can be taken: any time of your day; with or without meals; and works 24/7.

    01:12-01:20
    [Standing in his kitchen, talking to camera; at airport, pulling suitcase behind him]

    CLAYTON: Well, at first it was a little bit daunting because I knew I was going to have to give myself an injection, and I was a little bit scared to do that.

    CAPTION: Reluctant

    01:20-01:27
    [Sitting down in seat at airport]

    CLAYTON: But once I got over that and learned what the benefits were of Trulicity, it was absolutely no problem, and since then, has been a great tool.

    CAPTION: Willing

    CAPTION: Trulicity can help lower your A1C.*

    CAPTION: *along with diet and exercise

    01:27-01:32
    [Ken and Chris sitting in a laboratory setting]

    KEN: My name is Ken. I'm an engineer, and I work for Eli Lilly.

    CAPTION: Ken; Advisor; Global Patient Safety Device Surveillance

    01:32-01:39
    [Ken and Chris sitting in lab; Chris writing on a board; Ken and Chris walking upstairs in their office building and talking]

    CHRIS: My name is Chris, and I'm an engineer that works at Eli Lilly. Medication works, but it only works when you can use a device.

    CAPTION: Christopher; Consultant Engineer; IDM Product Stewardship

    01:39-01:44
    [Chris writing on board; Ken looking on]

    CHRIS: So, we've designed this to make it as simple and convenient as possible.

    01:44-01:57
    [Chris and Ken sitting at laboratory table; Ken talking to camera]

    KEN: I had an experience which was very powerful watching an injection. There was a woman who used the device. You could tell she was visibly scared. She’d never given herself an injection before.

    CAPTION: Anxiety

    01:57-02:09
    [Ken talking to camera, gets emotional as he remembers the patient’s experience using Trulicity for the first time]

    KEN: She was able to successfully complete the injection using the Trulicity device, and she started crying. It wasn't because she was sad or scared. It was because she was so happy and proud of herself.

    CAPTION: Pride

    02:09-02:14
    [Clayton standing in his kitchen, talking to camera]

    CLAYTON: When I used it for the first time, it was simple, it was easy, and I started to see results rather quickly.

    CAPTION: Trulicity starts working with your body from the first dose.

    02:14-02:20
    [Close-up of green button on bottom of Trulicity pen; Lynda, sitting in her creative space, talking to camera]

    LYNDA: You simply push a button. It injects quickly. It retracts quickly.

    02:20-02:26
    [Chris sitting at laboratory table with Ken]

    CHRIS: And you are in control of when you start it, and we also have really good feedback for when it’s done. It gives you a nice click.

    CAPTION: Ownership

    02:26-02:32
    [Clayton walking through airport; standing in his kitchen, talking to camera; talking on his cell phone at the airport]

    CLAYTON: I only take Trulicity once a week, and for a guy that's busy and on the road all the time, I don't have to worry about it.

    CAPTION: Once-weekly Trulicity is designed to fit into your busy life.

    02:32-02:40
    [Clayton pulling his suitcase into a hotel room; video chatting with his daughter while he sits on bed in hotel]

    NARRATOR: Trulicity is for type 2 diabetes. It isn't for people with type 1 diabetes or children under 10 years of age.

    CAPTION: Tell your healthcare provider if you are nursing, pregnant, or plan to be or are scheduled to have surgery or other procedures that use anesthesia or deep sleepiness

    02:40-02:49
    [Close-up of female patient holding Trulicity pen in doctor’s office; Lynda working on her jewelry]

    NARRATOR: Don't take Trulicity if you're allergic to it, you or your family have medullary thyroid cancer, or multiple endocrine neoplasia syndrome type 2.

    02:49-03:00
    [Lynda making jewelry; Clayton video chatting in hotel room]

    NARRATOR: Stop Trulicity and call your health care provider right away if you have an allergic reaction, a lump or swelling in your neck, severe stomach pain, vision changes or diabetic retinopathy.

    CAPTION: Symptoms may include swelling of your face or throat, problems breathing or swallowing, severe rash or itching, dizziness, or rapid heartbeat

    03:00-03:09
    [Lynda making jewelry; Clayton looking at computer screen with his doctor in her office]

    NARRATOR: Serious side effects may include pancreatitis and gallbladder problems. Taking Trulicity with sulfonylurea or insulin raises low blood sugar risk.

    CAPTION: Tell your doctor right away if you experience upper stomach pain, yellow skin or eyes, fever, or clay-colored stools

    CAPTION: Trulicity is not recommended for people with severe stomach or intestinal problem. Tell your doctor if you have history of diabetic retinopathy.

    03:09-03:20
    [Close-up of Lynda’s hands as she is creating jewelry; Lynda looking at the Trulicity pen with her doctor]

    NARRATOR: Side effects include nausea, vomiting and diarrhea, which can lead to dehydration and may worsen kidney problems.

    CAPTION: Side effects include nausea, diarrhea, vomiting, decreased appetite, indigestion, belly pain, and fatigue

    03:20-03:28
    [Dr. Eden in her office, talking to camera]
    DR. EDEN: By using Trulicity, we are giving back what the body’s dysfunctional in, and so any time you can do that, you make the body work better.

    CAPTION: Trulicity is a prescription medicine

    03:28-03:33
    DR. EDEN: When you can have efficacy and simplicity, that's what really Trulicity says.

    03:33-03:39
    [Standing in his kitchen, talking to camera]

    CLAYTON: You know, I’d tell anybody with diabetes that "you can do this,"

    CAPTION: Confidence

    03:39-03:48
    [Standing outside of her home, looking at the landscape; Trulicity logo; Lilly logo]

    LYNDA: And even a little bit easier is fantastic.

    NARRATOR: Ask your doctor about once-weekly Trulicity.

    CAPTION: Once weekly Trulicity® (dulaglutide) injection 0.5 mL, 0.75 mg, 1.5 mg, 3.0 mg, 4.5 mg

    CAPTION: Please see Instructions for Use included with the pen.

    CAPTION: See full Prescribing Information on our website, Trulicity.com

    03:48-03:53
    CAPTION: Participants received compensation for their appearance.

    CAPTION: Trulicity® and its delivery device base are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates. Trulicity is available by prescription only.

    CAPTION: PP-DG-US-4948 12/2024 ©Lilly USA, LLC 2024. All rights reserved.

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    SAFETY SUMMARY WITH WARNINGS

    Warnings:

    Trulicity may cause tumors in the thyroid, including thyroid cancer. Watch for possible symptoms, such as a lump or swelling in the neck, trouble swallowing, hoarseness, or shortness of breath. If you have any of these symptoms, tell your healthcare provider.

    • Do not use Trulicity if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC).
    • Do not use Trulicity if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
    • Do not use Trulicity if you are allergic to dulaglutide or other ingredients in Trulicity.

    Ask your healthcare provider how to recognize the serious side effects below and what to do if you think you have one:

    Inflamed pancreas (pancreatitis). Stop using Trulicity and call your healthcare provider right away if you have severe pain in your stomach area (abdomen), with or without vomiting, that will not go away. You may feel the pain from your abdomen to your back.
    Low blood sugar (hypoglycemia). Your risk for getting low blood sugar may be higher if you use TRULICITY with another medicine that can cause low blood sugar, such as a sulfonylurea or insulin.
    Signs and symptoms of low blood sugar may include dizziness or light-headedness, confusion or drowsiness, headache, blurred vision, slurred speech, fast heartbeat, sweating, hunger, shakiness, feeling jittery, weakness, anxiety, irritability, or mood changes.
    Serious allergic reactions. Stop using Trulicity and get medical help right away if you have any symptoms of a serious allergic reaction which may include swelling of your face, lips, tongue or throat, problems breathing or swallowing, severe rash or itching, fainting, or feeling dizzy, or very rapid heartbeat.
    Acute kidney injury. In people who have kidney problems, diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration). This may cause kidney problems to get worse.
    Severe stomach problems. Stomach problems, sometimes severe, have been reported in people who use Trulicity. Tell your healthcare provider if you have stomach problems that are severe or will not go away.
    Changes in vision. Tell your healthcare provider if you have changes in your eyesight (vision) during treatment with Trulicity.
    Gallbladder problems. Gallbladder problems have happened in some people who take Trulicity. Tell your healthcare provider right away if you get symptoms of gallbladder problems, which may include pain in your upper stomach (abdomen), fever, yellowing of skin or eyes (jaundice), clay-colored stools.
    Food or liquid getting into the lungs during surgery or other procedures that use anesthesia or deep sleepiness (deep sedation). Trulicity may increase the chance of food getting into your lungs during surgery or other procedures. Tell all your healthcare providers that you are taking Trulicity before you are scheduled to have surgery or other procedures.

    Common side effects

    The most common side effects of Trulicity include nausea, diarrhea, vomiting, abdominal pain and decreased appetite, indigestion, and fatigue.

    These are not all the possible side effects of Trulicity.

    Tell your healthcare provider if you have any side effects. You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch .

    Before using

    • Your healthcare provider should show you how to use Trulicity before you use it for the first time.
    • Before you use Trulicity, talk to your healthcare provider about low blood sugar and how to manage it.

    Review these questions with your healthcare provider:

    • Do you have other medical conditions, including problems with your pancreas, kidneys, liver, or stomach, or have a history of diabetic retinopathy (vision problems related to diabetes)?
    • Do you take other diabetes medicines, such as insulin or sulfonylureas?
    • Are you scheduled to have surgery or other procedures that use anesthesia or deep sleepiness (deep sedation)?
    • Are you pregnant or plan to become pregnant or breastfeeding or plan to breastfeed?
    • Do you take any other prescription medicines or over-the-counter drugs, vitamins, or herbal supplements?

    How to take

    • Read the Instructions for Use that come with Trulicity.
    • Use Trulicity exactly as your healthcare provider says.
    • Do not share your Trulicity pen, syringe, or needles with another person.
    • Do not give Trulicity to other people.
    • If you take too much Trulicity, call your healthcare provider or seek medical advice promptly.

    Learn more

    Trulicity is a prescription medicine. For more information, call 1-844-TRU-INFO (1-844-878-4636) or go to www.TRULICITY.lilly.com.

    This summary provides basic information about Trulicity but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your healthcare provider. Be sure to talk to your healthcare provider about Trulicity and how to take it. Your healthcare provider is the best person to help you decide if Trulicity is right for you.

    DG CON HL BS 11NOV2024

    Trulicity® and its delivery device base are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

    INDICATIONS

    Trulicity® (Trῡ-li-si-tee) is for adults and children 10 years of age and older with type 2 diabetes used along with diet and exercise to improve blood sugar (glucose). Trulicity is also used in adults with type 2 diabetes to reduce the risk of major cardiovascular events (problems having to do with the heart and blood vessels) such as death, heart attack, or stroke in people who have heart disease or multiple cardiovascular risk factors.

    • It is not known if Trulicity can be used in people who have had inflammation of the pancreas (pancreatitis). Trulicity is not for use in people with type 1 diabetes and is not recommended for use in people with severe stomach or intestinal problems. It is not known if Trulicity is safe and effective in children under 10 years of age.
    • Trulicity is given through an injection (needle). You take it once a week by injecting it under the skin of your stomach, thigh, or upper arm.

      For more information:
      call 1-844-TRU-INFO
      (1-844-878-4636)

      This site is intended for US residents ages 18 and over.
      PP-DG-US-3169 12/2024 ©Lilly USA, LLC 2024. All rights reserved.
      TRICARE® is a registered trademark of the Department of Defense (DoD), DHA.
      Trulicity® and its delivery device base are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

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